Continued Availability of the Tungsten-188/Rhenium-188 Generator to Enhance Therapeutic Utility of <sup>188</sup>Re

Authors

  • F.F. (Russ) Knapp Emeritus Medical Radioisotopes Program, Oak Ridge National Laboratory (ORNL), P.O. Box, 2008, Oak Ridge, Tennessee, USA 37831-6229

Keywords:

Beta emitters, Bolus concentration, Radionuclide generator, Radionuclide therapy, Rhenium-188, Tungsten-188

Abstract

Rhenium-188 (188Re) is a high energy beta-emitting radioisotope of widespread interest for use in nuclear medicine, oncology and other therapeutic applications. High energy beta emission (16.9 hour half-life) with Emax 2.12 MeV and gamma emission at 155 keV (15 %) are key factors for effective therapy and imaging for tissue kinetics and dosimetry evaluation. Moreover, on-demand availability of 188Re in a highly reproducible manner from the 188W/188Re generator system is an important capability for installation in a hospital-based or a central radiopharmacy for cost effective availability of no-carrier-added (NCA) 188Re. Because of the long 69.7 day half-life of the188W generator parent, the use of well-established post 188Re elution specific volume concentration technology allow generators to have a useful/predictable operational shelf-life of a few months. This paper provides a holistic review of the development, availability and use of the 188W/188Re generator prototypes.

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Published

2017-07-31

Issue

2017: Special Issue - 188Rhenium, the new Workhorse of Radio Nuclide Therapy: Concepts to Clinical Use

Section

Articles

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