Optimized Production Assessment, Compartmental Modeling and Dosimetric Evaluation of 177Lu- PSMA-617 for Clinical Trials

Authors

  • Mehdi Sharifi Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran, Postal code: 14155-1339
  • Hassan Yousefnia Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran, Postal code: 14155-1339
  • Ali Bahrami-Samani Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran, Postal code: 14155-1339
  • Amir Reza Jalilian Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran, Postal code: 14155-1339
  • Samaneh Zolghadri Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran, Postal code: 14155-1339
  • Mahdokht Vaez-Tehrani Energy Engineering and Department of Physics, Amir Kabir University of Technology, Tehran, Iran
  • Stephan Maus Clinic of Nuclear Medicine, University Medical Centre Mainz, Langenbeckstrasse 1, D-55131 Mainz, Germany

Keywords:

Biodistribution, Lu-177, PSMA-617, SPECT imaging, Compartmental modeling.

Abstract

177Lu-PSMA-617 was prepared at the optimized conditions (95°C, 15-18 µg peptide, 35-40 min; solid phase purification) using 177Lu obtained from 176Lu(n, γ)177Lu reaction(>98%, ITLC, HPLC, S.A. 22-24 TBq/mM) followed by stability (up to 48 h), biodistribution studies (up to 168 h), planar imaging, compartmental modeling and dosimetry estimations via Sparks’s extrapolation method in human organs. Kidney is the critical organ with the dose of 0.067 mGy/MBq and the radiopharmaceutical can be safely used in trials considering the human dose.

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Published

2017-11-04

Issue

Vol. 4 No. 2 (2017)

Section

Articles

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