https://www.cosmosscholars.com/phms/index.php/jtpr/issue/feed 2017-07-07T05:48:41-04:00 Support Manager support@cosmosscholars.com Open Journal Systems <p><strong>Journal of Translational Proteomics Research </strong>is a scientific journal providing a scholarly forum for novel scientific research in the field of translational proteomics. It covers all areas of human proteomics using multi-disciplinary approaches to untangle complex disease processes .Proteins are fundamental parts of living organisms, as they are the main components of the physiological metabolic pathways of cells. The cause of most human disease lies in the functional dysregulation of protein interactions. Proteomics, which includes the study of cellular protein interactions, has evolved from advances in scientific knowledge and technology.</p> https://www.cosmosscholars.com/phms/index.php/jtpr/article/view/757 2017-06-22T06:07:15-04:00 Yuriy Kit kit@cellbiol.lviv.ua

<p class="04-abstract">The mini review is focused on the analysis of published data and the results obtained by author with co-workers about biological activity of anti-DNA (“cationic”) and anti-histone Н1 (“anionic”) auto-antibodies linked with autoimmunity and oncology. The feathures of anti-DNA and-anti histone auto- antibodies, which might be engaged in regulation of tumor cell progressing, are considered.</p>

2017-06-21T00:00:00-04:00 Copyright (c) https://www.cosmosscholars.com/phms/index.php/jtpr/article/view/763 2017-07-07T05:48:41-04:00 Chien-Sheng Chen info@cosmosscholars.com Pramod Shah cchen103@gmail.com

Combination of existing antibiotics have been introduced to increase the efficacy for a long time. Synergistic combinations of antibiotics are most desirable due to reduction of doses, toxicity and side effects of the individual antibiotic as well as prolonging in evolution of antibiotic resistance. Recently, antimicrobial peptides (AMPs) are gaining attention as viable alternatives to antibiotics due to the broad spectrum of activities and abundantly present in multicellular organisms that act against invading microbes. The combination of AMPs and conventional antibiotics enables to reduce the overall cost and widen the power of synergistic effects. Synergistic combinations are also reported among AMPs. Despite enormous advantages of synergistic combinations and several reports and uses in clinical medicine, only few underlying mechanisms are revealed. In this review, we overviewed the mechanisms of antimicrobial agents’ synergistic combinations and introduced the proteome chip approach for predicting new synergistic combinations and deciphering the synergy mechanisms.

2017-07-07T00:00:00-04:00 Copyright (c)